Wrigleyville has been pretty safe historically.
M<y wife grew up in Chicago and we lived there 20 years, her family still lives there. We get back there like ten times a year. Her brother is a fairly recently retired police detective. The people we see live in the city, not the burbs.
All I can tell you is pretty much everyone we know there doesn't take the subway at night (or even the day) anymore, they Uber/Lyft.
They even avoid the Magnificent Mile after dark. That never used to be true. It's been different since Covid. Areas that used to be 100% safe now carry a chance of crime.
I love Chicago and I have no fear about going there. But you have to keep your eyes open and don't put yourself in spots in which you could be vulnerable. Just common sense, basically. Also, I'm not saying you'll get shot - more a risk of pick pockets, robbery etc.
Take an Uber at night.